75000 - Document - Document and Entity Information
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75010 - Statement - Condensed consolidated balance sheets
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75020 - Statement - Condensed consolidated balance sheets (Parenthetical)
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75030 - Statement - Condensed consolidated statements of operations and comprehensive (loss) income
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75040 - Statement - Condensed consolidated statements of stockholders' equity
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75050 - Statement - Condensed consolidated statements of cash flows
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995455 - Disclosure - Nature of the Business
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995465 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements
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995475 - Disclosure - Fair Value Measurements
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995495 - Disclosure - Accrued and Other Current Liabilities
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995505 - Disclosure - Commitments and Contingencies
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995515 - Disclosure - License and Collaboration Agreements
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995525 - Disclosure - Equity Incentive Plans
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995535 - Disclosure - Net (Loss) Income Per Share
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995545 - Disclosure - Income Taxes
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995555 - Disclosure - Segment Information
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995565 - Disclosure - Subsequent Events
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995575 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)
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995585 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Tables)
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995595 - Disclosure - Fair Value Measurements (Tables)
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995615 - Disclosure - Accrued and Other Current Liabilities (Tables)
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995625 - Disclosure - Commitments and Contingencies (Tables)
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995635 - Disclosure - License and collaboration agreements (Tables)
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995645 - Disclosure - Equity Incentive Plans (Tables)
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995655 - Disclosure - Net (Loss) Income Per Share (Tables)
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995665 - Disclosure - Segment Information (Tables)
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995675 - Disclosure - Nature of the Business - Additional Information (Details)
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995685 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Cash and Cash Equivalents and Restricted Cash (Details)
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995695 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Additional Information (Details)
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995705 - Disclosure - Fair Value Measurements - Schedule of Financial Assets Measured at Fair Value on Recurring Basis and Level of Fair Value Hierarchy Utilized (Details)
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995715 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995745 - Disclosure - Accrued and Other Current Liabilities - Schedule of Accrued and Other Current Liabilities (Details)
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995755 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995765 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Lease Payments Under Non-Cancellable Leases (Details)
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995775 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Lease Payments Under Non-Cancellable Leases (Details) 2
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995785 - Disclosure - Commitments and Contingencies - Summary of Lease Balances (Details)
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995795 - Disclosure - Commitments and Contingencies - Summary of Weighted Average Remaining Lease Term and Weighted Average Discount Rate of Operating Leases (Details)
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995805 - Disclosure - License and Collaboration Agreements - Additional Information (Details)
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995815 - Disclosure - License and collaboration agreements - Summary of Transaction Price Allocated to Each Performance Obligation, in Addition to Revenue Activity (Details)
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995825 - Disclosure - Equity Incentive Plans - Additional Information (Details)
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995835 - Disclosure - Equity Incentive Plans - Summary of Stock-based Compensation Expense (Details)
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995835 - Disclosure - Equity Incentive Plans - Summary of Stock-based Compensation Expense (Details) [Default]
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995845 - Disclosure - Net (Loss) Income Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details)
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995855 - Disclosure - Net (Loss) Income Per Share - Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss (Income) Per Share (Details)
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995865 - Disclosure - Net (Loss) Income Per Share - Additional Information (Details)
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995875 - Disclosure - Income Taxes - Additional Information (Details)
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995885 - Disclosure - Segment Information - Additional Information (Details)
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995895 - Disclosure - Segment Information - Summary of Segment Information (Details)
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995905 - Disclosure - Subsequent Events - Additional Information (Details)
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ADOA
ADOA [Member]
ADOA.
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from maturity of marketable securities
MECP2 [Member]
MECP2.
MECP2
Number of shares of common stock reserved for issuance
Common Stock, Capital Shares Reserved for Future Issuance
Present value of lease liabilities
Operating Lease, Liability, Total
Operating lease liabilities
Operating Lease, Liability
Interest Expense, Operating and Nonoperating
Interest Expense, Operating and Nonoperating, Total
Interest expense
Interest expense
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Collaborative Arrangement, Initial Transaction Price
Collaborative arrangement, initial transaction price.
Initial transaction price
SYNGAP1 [Member]
SYNGAP1.
SYNGAP1
Commitments and contingencies (Note 6)
Commitments and Contingencies
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted-average number of common shares, diluted
Weighted Average Number of Shares Outstanding, Diluted
Diluted
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Interest receivable
Interest Receivable, Current
Operating lease term
Lessee, Operating Lease, Term of Contract
Minimum
Minimum [Member]
Letter of Credit [Member]
Letter of Credit
Upfront Consideration Related To Performance Obligations
Upfront consideration related to performance obligations.
Upfront consideration related to performance obligations
Eligible milestone payments receivable
Eligible Milestone payments receivable
Eligible milestone payments receivable.
Fair Value, Recurring
Fair Value, Recurring [Member]
Maximum aggregate offering price
Maximum Aggregate Offering Price
Maximum aggregate offering price.
Development Milestone Payments Receivable
Development milestone payments receivable.
Development milestone receivable
Common stock, shares issued
Common Stock, Shares, Issued
Segment Reporting [Line Items]
Business Combination, Contingent Consideration, Liability
Business Combination, Contingent Consideration, Liability, Total
Consideration
Income tax benefit
Income Tax Expense (Benefit)
Provision for income taxes
Provision for income taxes
Schedule of Accrued and Other Current Liabilities
Schedule Of Accrued And Other Current Liabilities Table [Text Block]
Schedule of accrued and other current liabilities.
Counterparty Name
Counterparty Name [Domain]
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3
Fair value assets, transfers out of level 3, amount
Marketable Securities, Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Subsequent Event Type [Domain]
Operating Lease Liability Noncurrent Statement Of Financial Position Extensible List
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Less imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
License And Collaboration Agreement [Line Items]
License And Collaboration Agreement [Line Items]
License and collaboration agreement.
Revenue, payment terms
Revenue, Performance Obligation, Required Payment Terms
Revenue, performance obligation, required payment terms.
Restricted Cash, Current
Restricted cash - current
Restricted cash - current
Warrants to purchase shares of common stock.
Warrants To Purchase Shares Of Common Stock
Warrants to purchase of common stock
Income taxes.
Income Taxes [Line Items]
Income Taxes [Line Items]
Nonoperating Income (Expense)
Total other income (expense)
Operating lease cost per year
Operating Lease Cost Per Year
Operating lease cost per year.
Pre-funded Warrants.
Prefunded Warrants [Member]
Pre-Funds Warrants
Debt Securities, Available-for-Sale, Noncurrent
Marketable securities - long-term
Income Statement [Abstract]
Schedule Of Allocated Transaction Price, In Addition To Revenue Activity [Table Text Block]
Schedule of allocated transaction price, in addition to revenue activity.
Summary of Transaction Price Allocated to Each Performance Obligation, in Addition to Revenue Activity
Receivables
Receivables, Net, Current
Receivables, Net, Current, Total
Underwritten Public Offering.
Underwritten Public Offering [Member]
Underwritten Public Offering
Income Tax Jurisdiction [Axis]
Percentage of Sublease Annual Rent Increases
Percentage of sublease annual rent increases.
Percentage of sublease annual rent increases
Commercial Milestone Payments Receivable
Commercial milestone payments receivable.
Commercial milestone receivable
Summary of Significant Accounting Policies [Line Items]
Summary of significant accounting policies.
Earnings Per Share, Basic, Total
Basic
Basic
Net (loss) income per share, basic
Operating Lease, Impairment Loss
Impairment of right of use asset
Document Period End Date
Document Period End Date
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Commitments and contingencies.
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Common stock, shares authorized
Common Stock, Shares Authorized
Statement of Stockholders' Equity [Abstract]
Future minimum lease payments under non-cancellable leases
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Accounting Standard Update 2016-02 [Member]
Accounting Standard Update 2016-02.
ASU 2016-02
Revenue, description of payment terms
Revenue, Performance Obligation, Description of Payment Terms
Other Comprehensive Income (Loss), Net of Tax
Total other comprehensive (loss) gain
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Assets
Total assets
Title of 12(b) Security
Title of 12(b) Security
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Summary of Stock-based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Option granted to purchase shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Title and Position [Domain]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Directors Or Officers Except Corporate Secretary CEO, COO And CBO [Member]
Directors Or Officers Except Corporate Secretary CEO, COO And CBO.
Percentage Of Remaining Development Costs
Percentage of remaining development costs.
Percentage of remaining development costs
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
2026
Zorevunersen [Member]
Zorevunersen.
Zorevunersen
Lessee, Operating Lease, Liability, to be Paid, Year One
2027
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Segment Reporting [Table Text Block]
Summary of Segment Information
Other non-program costs - SG&A
Other Non Program Costs Sales, General And Administrative [Member]
Other non program costs sales, general and administrative.
Shares Sold as Part of Controlled Equity Offering Sales Agreement Net of Commissions, Value
Shares sold as part of controlled equity offering sales agreement net of commissions, value.
Shares sold as part of controlled equity offering sales agreement, net of commissions
Total stockholders’ equity
Balance
Balance
Equity, Attributable to Parent
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Income taxes
Income Tax Disclosure [Text Block]
Income Tax Jurisdiction, Domestic State and Local [Member]
State
Nature Of Business [Line Items]
Nature Of Business [Line Items]
Earnings Per Share [Text Block]
Net (loss) income per share
Number of reportable segments
Basis of Presentation and Consolidation
Basis of Accounting, Policy [Policy Text Block]
Segment Reporting, Expense Information Used by CODM, Type [Extensible Enumeration]
Summary of Significant Accounting Policies [Table]
Summary of significant accounting policies.
Interest income (expense), net
Interest Income (Expense), Nonoperating
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Marketable Securities, Unrealized Gain
Proceeds from issuance of common stock upon exercise of stock options
Proceeds from Stock Options Exercised
Upfront Payment Received
Upfront payment received.
Upfront Payment received
Affront payment received
Statistical Measurement
Statistical Measurement [Axis]
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive (loss) income:
Money Market Funds
Money Market Funds [Member]
Entity Interactive Data Current
Entity Interactive Data Current
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Common Stock, Value, Issued
Common stock, par value of $0.0001 per share; 300,000,000 shares authorized, 62,402,595 and 58,921,999 shares issued and outstanding as of June 30, 2026 and December 31, 2025, respectively
Schedule of Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
US Government Debt Securities
US Government Agencies Debt Securities [Member]
US Government and US Government Agency Debt Securities
Nature of the business
Business Description and Basis of Presentation [Text Block]
Total liabilities
Liabilities
Product and Service [Axis]
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Total
Level 3
Fair Value, Inputs, Level 3 [Member]
Revenue Related To Upfront Fee Pertaining To Discontinued Programs
Revenue related to upfront fee pertaining to discontinued programs.
Revenue related to upfront fee pertaining to discontinued programs
Total cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Total operating expenses
Operating Expenses
Operating expenses
Share Price
Price per share
Changes in assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Issuance of common stock, Shares
Stock Issued During Period, Shares, New Issues
Number of stock issued and sold
2014 Plan
Two Thousand And Fourteen Equity Incentive Plan [Member]
2014 Equity Incentive Plan.
Shares sold as part of controlled equity offering sales agreement shares.
Shares Sold As Part Of Controlled Equity Offering Sales Agreement Shares
Shares sold as part of controlled equity offering sales agreement, Shares
Subsequent Events [Text Block]
Subsequent events
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3
Fair value assets, transfers into level 3, amount
Level 2
Fair Value Hierarchy and NAV [Axis]
Short-Term Debt, Type [Axis]
Corporate Bonds
Corporate Debt Securities [Member]
Non Rule 10b5-1 Arr Modified Flag
Non Rule 10b5-1 Arr Modified Flag.
Debt Securities, Available-for-Sale
Marketable Securities, Fair Value
Total Marketable Securities
Operating Lease, Liability, Current
Current portion of operating lease liabilities
Current portion of operating lease liabilities
Option Indexed to Issuer's Equity, Type [Domain]
Operating lease, existence of option to extend [true false]
Lessee, Operating Lease, Existence of Option to Extend [true false]
Total liabilities and stockholders’ equity
Liabilities and Equity
2019 Plan
Two Thousand And Nineteen Equity Incentive Plan [Member]
2019 equity incentive plan.
Lessee, Operating Lease, Liability, to be Paid, Year Two
2028
Research and Development Expense, Total
Research and development
Research and Development Expense
Document Fiscal Period Focus
Document Fiscal Period Focus
Revenue, Remaining Performance Obligation, Amount
Transaction Price Allocated
Lease Commencement on December 15, 2021
Lease Commencement Two Thousand And Twenty One [Member]
Lease commencement, two thousand and twenty one.
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Title and Position [Axis]
Unaudited Interim Financial Information
Unaudited Interim Financial Information Policy [Text Block]
Unaudited interim financial information.
Lease Extension End Date April 30, 2025
Lease Extension End Date [Member]
Lease extension end date.
Sale of Stock
Sale of Stock [Axis]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net increase in cash, cash equivalents and restricted cash
Entity Current Reporting Status
Entity Current Reporting Status
Level 1
Fair Value, Inputs, Level 1 [Member]
Total accrued and other current liabilities
Accrued and other current liabilities
Accrued And Other Current Liabilities
Accrued and other current liabilities.
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Schedule of Cash and Cash Equivalents and Restricted Cash
Schedule Of Cash Cash Equivalents And Restricted Cash And Equivalents Table [Text Block]
Schedule of cash, cash equivalents and restricted cash and equivalents.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss (Income) Per Share
Financial Instrument
Financial Instrument [Axis]
Document Transition Report
Document Transition Report
Commitments and Contingencies Disclosure [Abstract]
Subsequent Event [Line Items]
Accounting Standards Update
Accounting Standards Update [Domain]
Current liabilities:
Liabilities, Current [Abstract]
Share-Based Payment Arrangement [Abstract]
Proceeds from issuance of common stock in controlled equity offering sales agreements
Proceeds From Issuance of Common Stock in Controlled Equity Offering Sales Agreement
Proceeds from issuance of common stock in controlled equity offering sales agreements
Common Stock
Common Stock [Member]
Accounting Standards Update
Accounting Standards Update [Axis]
Statistical Measurement
Statistical Measurement [Domain]
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Prepaid expenses
Prepaid Expense, Current
Prepaid Expense, Current, Total
Director [Member]
Board of Directors
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted-average number of common shares, basic
Weighted Average Number of Shares Outstanding, Basic
Basic
Assets
Assets [Abstract]
Issuance Of Vested Restricted Stock Units And Performance Stock Units Shares
Issuance of vested restricted stock units and performance stock units
Issuance of vested restricted stock units and performance stock units, Shares
Operating leases expense
Operating Lease, Expense
Entity Central Index Key
Entity Central Index Key
Percentage of development costs
Percentage Of Development Costs
Percentage of development costs.
Antidilutive Securities
Antidilutive Securities [Axis]
Other current liabilities
Other Liabilities, Current
Current Fiscal Year End Date
Current Fiscal Year End Date
Document Quarterly Report
Document Quarterly Report
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Operating lease expiration date
Lease Expiration Date
Level 2
Fair Value, Inputs, Level 2 [Member]
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash (used in) provided by operating activities
Entity incorporation state name
Entity Incorporation State Country Code
Entity Incorporation, State or Country Code
Shares sold as part of controlled equity offering sales agreement, net of commissions, Shares
Shares Sold as Part of Controlled Equity Offering Sales Agreement Net of Commissions, Shares
Shares sold as part of controlled equity offering sales agreement, net of commissions, shares.
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Diluted
Net (loss) income per share, diluted
Weighted average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Other External Program Costs [Member]
Other external program costs.
Other external program costs
Net (loss) income
Net (loss) income
Base Prospectus
Base Prospectus [Member]
Base prospectus.
Total operating lease liabilities
Operating Lease Liability Excluding Leases Entered Access Yet To Be Granted
Operating lease liability excluding leases entered access yet to be granted.
Option Indexed to Issuer's Equity, Type [Axis]
Commitments and contingencies
Commitments and Contingencies Disclosure [Text Block]
Reduction in the carrying amount of right of use assets
Reduction In Carrying Amount Of Operating Lease Right Of Use Assets
Reduction in carrying amount of operating lease right of use assets
Lease Contractual Term
Lease Contractual Term [Domain]
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive (loss) income
Number of options to renewal operating lease term
Number Of Renewal Option To Extend Operating Lease Terms
Number of renewal option to extend operating lease terms.
Income Tax Jurisdiction [Domain]
Measurement Frequency
Measurement Frequency [Domain]
Equity Components
Equity Components [Axis]
Cash flows from investing activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
License And Collaboration Agreement [Abstract]
License and collaboration agreement.
Operating lease commencement date
Operating Lease Commencement Date
Operating lease commencement date.
Payroll And Other Personnel Costs Sales, General And Administrative [Member]
Payroll and other personnel costs sales, general and administrative.
Payroll and other personnel costs - SG&A
Statement of Cash Flows [Abstract]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Income Tax Disclosure [Abstract]
Average grant date fair value per share under the plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Fair value measurements
Fair Value Disclosures [Text Block]
Debt Securities Available For Sale Maturity Period Long Term
Debt Securities Available For Sale Maturity Period Long Term.
Weighted average maturity long term marketable securities period
Rule 10b5-1 Arr Modified Flag
Rule 10b5-1 Arr Modified Flag.
2019 ESPP
Two Thousand And Nineteen Employee Stock Purchase Plan [Member]
2019 Employee Stock Purchase Plan.
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain (loss) on marketable securities
Unrealized (loss) gain on marketable securities
Anti-dilutive securities excluded from computation of earnings per share, amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Counterparty Name
Counterparty Name [Axis]
Lease Commencement on April 2022
Lease Commencement Two Thousand And Twenty Two [Member]
Lease commencement, two thousand and twenty two.
Marketable Securities, Fair Value
Total Marketable Securities
Marketable securities - current
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Gain (Loss)
Number of common shares available for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Deferred revenue
Increase (Decrease) in Deferred Revenue
Edward Kaye
Edward Kaye [Member]
Edward Kaye.
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive (loss) gain:
Southampton Agreement
Southampton Agreement [Member]
Southampton Agreement.
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Estimated variable consideration related to cost reimbursements for global development activities
Collaborative Arrangement, Estimated Variable Consideration Related To Cost Reimbursements For Global Development Activities
Collaborative arrangement, estimated variable consideration related to cost reimbursements for global development activities.
Marketable Securities, Unrealized Loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Document Type
Document Type
Issuance Of Common Stock Upon Follow On Offering Net Of Underwriting Discounts Commissions And Offering Costs Shares
Issuance of common stock upon follow on offering net of underwriting discounts commissions and offering costs shares.
Issuance of common stock and warrants upon follow-on offering, net of underwriting discounts, commissions, and offering costs, Shares
Cash flows from operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Employee Stock Option
Subsequent Event [Member]
Subsequent Event
Operating Income (Loss)
(Loss) income from operations
Service Revenue
Service [Member]
Segment Reporting [Table]
Entity File Number
Securities Act File Number
Income Tax Jurisdiction, Domestic Federal [Member]
Federal
Schedule of Future Minimum Lease Payments Under Non-Cancellable Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Location, Statement of Income, Balance [Axis]
Accumulated Deficit
Retained Earnings [Member]
Marketable securities
Investment in Debt and Equity Securities and Other Trading Assets [Text Block]
Entity Registrant Name
Entity Registrant Name
Accounting Policies [Abstract]
Depreciation, Total
Depreciation
Depreciation
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net (loss) income
Sales, general and administrative
Selling, General and Administrative Expense
Selling, General and Administrative Expense, Total
Operating lease, renewal term
Lessee, Operating Lease, Renewal Term
Entity Address, Address Line One
Entity Address, Address Line One
Accrued and other current liabilities
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Biogen International GmbH [Member]
Biogen International GmbH
Biogen International GmbH
Issuance of common stock upon exercise of stock options, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Net proceeds from common stock and pre-funded warrants
Proceeds from Issuance or Sale of Equity, Total
Proceeds from Issuance or Sale of Equity
Net proceeds from common stock
Total current assets
Assets, Current
Percentage of increase in reserved common shares
Percentage of increase in reserved common shares.
Percentage Of Increase In Reserved Common Shares
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Two Thousand Twenty Six Registration Statement [Member]
Two thousand twenty six registration statement.
2026 Registration Statement
Entity Small Business
Entity Small Business
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Summary of significant accounting policies and recent accounting pronouncements
Significant Accounting Policies [Text Block]
Twenty Twenty Five Registration Statement [Member]
Twenty twenty five registration statement.
2025 Registration Statement
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Sales Agreement Prospectus
Sales Agreement Prospectus [Member]
Sales agreement prospectus.
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Earnings Per Share [Abstract]
Net (loss) income per share:
Plan Name
Plan Name [Axis]
Subsequent Event Type [Axis]
Product and Service [Domain]
Non-refundable upfront payment
Collaborative Arrangement, Non Refundable Upfront Payment
Collaborative arrangement, non refundable upfront payment.
Measurement Frequency
Measurement Frequency [Axis]
Cash flows from financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Increase (decrease) in accounts payablea, accrued liabilities and opertaing leases.
Increase Decrease In Accounts Payable, Accrued Liabilities and Opertaing Leases
Accounts payable, accrued liabilities and lease liabilities
Liabilities, Noncurrent
Total long-term liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Area of space subject to operating lease
Area Of Space Subject To Operating Lease
Area of space subject to operating lease.
Equity Component
Equity Component [Domain]
Entity Address City Or Town
Entity Address, City or Town
Capital Expenditures Incurred but Not yet Paid
Property and equipment included in accrued expense and accounts payable
Restricted cash - long-term
Restricted cash
Restricted Cash, Noncurrent
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Marketable Securities [Table Text Block]
Summary of Marketable Securities
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Commercial Paper
Commercial Paper [Member]
Summary of Lease Balances
Summary Of Lease Balances Table [Text Block]
Summary of lease balances.
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Payroll And Other Personnel Costs Research And Development [Member]
Payroll and other personnel costs research and development.
Payroll and other personnel costs - R&D
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Weighted-average common shares outstanding:
Operating lease, option to extend
Lessee, Operating Lease, Option to Extend
Purchases of marketable securities
Purchases of marketable securities
Payments to Acquire Marketable Securities
Adrian Krainer [Member]
Adrian Krainer.
Nature Of Business [Table]
Nature Of Business [Table]
Statement [Table]
Statement [Table]
Area Of Space Subject To Sublease
Area of space subject to sublease.
Area of space subject to sublease
Deferred Revenue, Current, Total
Deferred revenue - current portion
Deferred Revenue, Current
Current deferred revenue
Biogen License Agreement
Biogen License Agreement [Member]
Biogen license agreement.
Stock based compensation expense
Share-Based Payment Arrangement, Expense
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
(Loss) income before income taxes
Entity Shell Company
Entity Shell Company
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by (used in) investing activities
Potential milestone payments receivable
Milestone Payments Receivable
Milestone payments receivable.
Statement [Line Items]
Statement [Line Items]
Deferred Revenue, Noncurrent, Total
Deferred revenue - net of current portion
Deferred Revenue, Noncurrent
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Accrued research and development costs
Accrued Research And Development Costs Current
Accrued research and development costs current.
Maximum
Maximum
Maximum [Member]
Weighted-average shares outstanding
Pro Forma Weighted Average Shares Outstanding, Diluted
Sale of Stock
Sale of Stock [Domain]
Investment Income, Interest
Interest income
Summary of Weighted Average Remaining Lease Term and Weighted Average Discount Rate of Operating Leases
Summary Of Weighted Average Remaining Lease Term And Weighted Average Discount Rate Of Operating Leases Table [Text Block]
Summary of weighted average remaining lease term and weighted average discount rate of operating leases.
Licensing Agreements [Member]
Licensing Agreements
License and Collaboration Agreement
Subsequent Events [Abstract]
Investments, Debt and Equity Securities [Abstract]
Assets, Current [Abstract]
Current assets:
Accrued professional costs
Accrued Professional Fees, Current
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Document Fiscal Year Focus
Document Fiscal Year Focus
Issuance Of Common Stock Upon Follow On Offering Net Of Underwriting Discounts Commissions And Offering Costs
Issuance of common stock upon follow on offering net of underwriting discounts commissions and offering costs
Issuance of common stock and warrants upon follow-on offering, net of underwriting discounts, commissions, and offering costs
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Security Deposit
Security deposit
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Commitments and contingencies.
Financial Instruments
Financial Instruments [Domain]
Operating Lease, Liability, Noncurrent
Non-current portion of operating lease liabilities
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Total
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Ending Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Beginning Balance
Allowance for credit losses
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Global Development Activity [Member]
Global development activity.
Global Development Activity
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
Security Exchange Name
Security Exchange Name
Revenue
Revenues, Total
Revenue
Revenues
Class of Warrant or Right, Exercise Price of Warrants or Rights
Common stock warrant, Offering price per share
Warrants excercise price
Entity Address State Or Province
Entity Address, State or Province
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted average period of unrecognized compensation cost expected to be recognized
Operating Lease, Right-of-Use Asset
Operating right-of-use assets
Amendment Flag
Amendment Flag
Equity incentive plans
Share-Based Payment Arrangement [Text Block]
Debt Securities Available For Sale Maturity Period Short Term
Debt Securities Available For Sale Maturity Period Short Term.
Weighted average maturity short term marketable securities period
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Sublease Income
Sublease terms commence
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense)
Other income
City Area Code
City Area Code
Issuance of common stock related to employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Acadia Agreement
Acadia Agreement [Member]
Acadia agreement.
Schedule of Financial Assets Measured at Fair Value on Recurring Basis and Level of Fair Value Hierarchy Utilized
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Operating Lease Liability Current Statement Of Financial Position Extensible List
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Rule10 B51 Trading Plan One [Member]
Rule10 B51 trading plan one.
Rule 10b5-1 Trading Plan One
License Revenue
License [Member]
Cash, Cash Equivalents and Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Operating expenses:
Operating Expenses [Abstract]
Accrued employee compensation costs
Accrued Employee Benefits, Current
Common stock, par value
Common Stock, Par or Stated Value Per Share
License And Collaboration Agreement [Table]
License And Collaboration Agreement [Table]
License and Collaboration Agreement.
Agreement Termination Impact Description
Agreement termination impact description.
Agreement termination impact description
Short-Term Debt, Type [Domain]
Total current liabilities
Liabilities, Current
Noncash Investing and Financing Items [Abstract]
Supplemental Disclosure of Non-Cash Investing and Financing Activities:
Total cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash—beginning of period
Cash, cash equivalents and restricted cash—end of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Annual base rent increase percentage for operating lease
Annual Base Rent Increase Percentage For Operating Lease
Annual base rent increase percentage for operating lease.
Segment Information
Segment Reporting [Text Block]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
License And Collaboration Agreement [Text Block]
License and collaboration agreement.
License and collaboration agreements
Trading Symbol
Trading Symbol
Subsequent Event [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Restricted stock units granted
Entity Emerging Growth Company
Entity Emerging Growth Company
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Amortization and accretion of marketable securities
Amortization And Accretion Of Marketable Securities
Amortization and accretion of marketable securities.
Plan Name
Plan Name [Domain]
Lease Commencement on January 1, 2025
Lease commencement, two thousand and twenty five.
Lease Commencement Two Thousand And Twenty Five [Member]
Other Liabilities, Noncurrent
Other long-term liabilities
Acadia Pharmaceuticals Inc.
Acadia Pharmaceuticals Inc [Member]
Acadia pharmaceuticals Inc.
Issuance of common stock related to employee stock purchase plan, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Twenty Twenty Two Registration Statement [Member]
Twenty twenty two registration statement.
2022 Registration Statement
Cover [Abstract]
Arthur Tzianabos [Member]
Arthur Tzianabos.
Two Thousand Twenty Five Registration Statement [Member]
Two thousand twenty five registration statement.
2025 Registration Statement
Marketable Securities [Table]
Marketable Securities [Table]
Weighted average remaining lease term in years
Operating Lease, Weighted Average Remaining Lease Term
Other non-program costs - R&D
Other Non Program Costs Research And Development [Member]
Other non program costs research and development.
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive (loss) income
Share-Based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Additional Paid in Capital, Total
Additional paid-in capital
Additional Paid in Capital
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net (loss) income to net cash provided by (used in) operating activities:
Fair Value Disclosures [Abstract]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalent
Payment For License And Collaboration Agreement
Payment for license and collaboration agreement.
Payment for license and collaboration agreement
Shares sold as part of controlled equity offering sales agreement value.
Shares Sold As Part Of Controlled Equity Offering Sales Agreement Value
Shares sold as part of controlled equity offering sales agreement
2023 Inducement Plan
Two Thousand Twenty Three Inducement Plan [Member]
Two thousand twenty three inducement plan.
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
IP License
IP License [Member]
IP license.
Payables and Accruals [Abstract]
Proceeds from Employee Stock Purchase Plan
Proceeds from Stock Plans
Entity Filer Category
Entity Filer Category
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Remaining upfront consideration
Remaining Upfront Consideration
Remaining upfront consideration.
Lease Contractual Term
Lease Contractual Term [Axis]
Proceeds from issuance of common stock net of commissions
Net Proceeds From Securities Issued In Connection With Shelf Registration
Net proceeds from securities issued in connection with shelf registration.
Increase (Decrease) in Accounts Receivable
Accounts receivable
Property, Plant and Equipment, Net, Total
Property and equipment, net
Property, Plant, and Equipment, after Accumulated Depreciation, Depletion, and Amortization
Revenue Recognized
Revenue from Contract with Customer, Excluding Assessed Tax
Balance, Shares
Balance, Shares
Shares, Outstanding
Segment Reporting [Abstract]
Performance stock units.
Performance Stock Units [Member]
Performance Stock Units
Other current assets
Other Assets, Current
Entity Address Postal Zip Code
Entity Address, Postal Zip Code
Statement of Financial Position [Abstract]
Local Phone Number
Local Phone Number